![]() ![]() ![]() Consequently, such combinations have been effective in controlling both local and systemic Candida and bacterial burn wound sepsis. These data suggest that the antimicrobial properties of nystatin, when combined with Silvadene and Furacin, remain effective. The average burnsize was greater than or equal to 29.44% total body surface area. These 90 patients were discharged without any documented signs of infection. Of the 93 patients treated, 90 had neither a major systemic bacterial nor a Candida sepsis, and none of these patients had associated localized burn wound sepsis during their hospital stays. On the basis of the in vitro results, 93 patients with acute burns were treated with the appropriate topical antimicrobials from April 1988 to September 1988. Conversely, Sulfamylon combined with nystatin lost its antimicrobial capability (93.3% resistance, p less than 0.001). Both Silvadene and Furacin combined with nystatin were equally effective against the microorganisms as were the individual drugs. Therefore we examined the susceptibility to nystatin of 165 clinical isolates, both gram-positive and gram-negative, to nystatin combined with Silvadene or Sulfamylon and 144 isolates to nystatin and Furacin. Store at room temperature away from moisture and heat.Pilot in vitro studies demonstrated that nystatin combined with Silvadene (silver sulfadiazine 1% ) or Furacin in a 1:1 ratio was equally effective against Candida albicans and ATCC strains of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, but Sulfamylon (Winthrop Pharmaceuticals, Winthrop, N.Y.) combined with nystatin demonstrated an antagonistic response. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Your symptoms may improve before the infection is completely cleared. Use this medicine for the full prescribed length of time. Your kidney function may also need to be tested. Silver Sulfadiazine Cream also helps to create an ideal environment that aids the skins natural healing process. It works by killing bacteria on the surface of the skin, and helps to prevent an infection from spreading or worsening. While using Silvadene, you may need frequent blood tests. Silver Sulfadiazine Cream is a topical antibiotic used to prevent or treat minor skin infections. Treated skin areas can be left uncovered, or you may use a gauze bandage if directed by your doctor. Burn wounds must be kept covered with this medicine at all times. Silver sulfadiazine cream is usually applied 1 or 2 times daily. Reapply the cream after bathing or water therapy. If needed, apply more cream to replace any medicine that has come off on bandages, clothing, or bed linens. This medicine should be applied in a layer about one 16th (1/16) of an inch thick, or 1.6 millimeters. Apply enough silver sulfadiazine to cover the affected area evenly. Take care to keep the treatment area as clean as possible to prevent further infection.Ĭlean the area to be treated as directed by your doctor. The person applying silver sulfadiazine to burn wounds should wear sterile disposable gloves. Wash your hands before and after applying silver sulfadiazine cream. Do not use Silvadene in larger or smaller amounts or for longer than recommended. You may report side effects to FDA at 1-80.įollow all directions on your prescription label. Call your doctor for medical advice about side effects. This is not a complete list of side effects and others may occur. (1) accurate preoperative and intraoperative determination of burn depth, (2) the. Severe skin reaction-fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. Topical Agents Used for Burns AGENT EFFECTIVENESS EASE OF USE Silvadene cream. Liver problems- nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes) or Kidney problems-red or pink urine, little or no urinating, swelling, rapid weight gain Pale or yellowed skin, dark colored urine, fever, confusion or weakness Sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing Įasy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin Silvadene may cause serious side effects. Get emergency medical help if you have any of these signs of an allergic reaction: hives difficult breathing swelling of your face, lips, tongue, or throat.Īlthough the risk of serious side effects is low when silver sulfadiazine is applied to the skin, side effects can occur if the medicine is absorbed into your bloodstream. ![]()
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