About 0.1 to 1.0% of people show hypersensitivity reactions such as rashes or erythema multiforme. Īpplication to large areas or to severe burns may lead to systemic absorption and lead to adverse effects similar to those of other sulfonamides. Burning and painful sensations are not uncommon, but are only temporary. Adverse effects Ī noninfection-related clear fluid may form on the wound's surface. For this reason, application of silver sulfadiazine is not recommended for most burns due to altered wound appearance and the frequency of required dressing changes. In addition to concerns regarding delayed wound healing, silver sulfadiazine is associated with sloughing of the wound surface that makes reassessment of wound depth difficult, and requires daily reapplication. Cochrane has raised concerns about delays in time to wound healing when SSD is used. Other reviews of the evidence have also concluded, " quality of the trials was limited". Another Cochrane systematic review from 2010 concluded, "There is insufficient evidence to establish whether silver-containing dressings or topical agents promote wound healing or prevent wound infection". A Cochrane review from 2013 found that most of the trials that met inclusion criteria for the review had methodological shortcomings and thus are of little use in assessing the efficacy of silver sulfadiazine in the healing of burn injuries. Tentative evidence has found other antibiotics to be more effective in the healing of superficial and partial thickness burn injuries therefore, it is no longer generally recommended. It is on the World Health Organization's List of Essential Medicines. Silver sulfadiazine was discovered in the 1960s. It is not recommended for use in children less than two months of age. It should not be used in pregnant women who are close to delivery. Caution should be used in those allergic to other sulfonamides. Other side effects include low white blood cell levels, allergic reactions, bluish grey discoloration of the skin, red blood cell breakdown, or liver inflammation. Ĭommon side effects include itching and pain at the site of use. Tentative evidence has found other antibiotics to be more effective, and therefore it is no longer generally recommended for second-degree (partial-thickness) burns, but is still widely used to protect third-degree (full-thickness) burns. If you are having difficulty accessing this website, please call or email us at 1-85 or so that we can provide you with the services you require through alternative means.Silver sulfadiazine, sold under the brand Silvadene among others, is a topical antibiotic used in partial thickness and full thickness burns to prevent infection. GoodRx works to make its website accessible to all, including those with disabilities. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. Truven Health and GoodRx make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. These products are provided 'AS IS' and 'as available' for use, without warranties of any kind, either express or implied. The use of the Truven Health products is at your sole risk.
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